Witchblade is an American comic book series published by Top Cow Productions, an imprint of Image Comics, from 1995 until present. The series was created by Top Cow editors Marc Silvestri and David Wohl, writers Brian Haberlin and Christina Z, and artist Michael Turner

The series previously starred Sara Pezzini, a tough-as-nails NYPD homicide detective who comes into possession of the Witchblade, a supernatural, sentient artifact with immense destructive and protective powers. The weapon has bonded with various women throughout history, the most recent being Danielle Baptiste. Others who have come into contact with the Witchblade include Cleopatra and Joan of Arc. Sara struggles to hone the awesome powers of the Witchblade and fend off those with a nefarious interest in it, especially entrepreneur Kenneth Irons. She also struggles to maintain a personal life.

The title was written largely by Christina Z and edited by David Wohl. There have been talks of a reunion[citation needed], though it is unclear if that will occur.

There have been many spin-off titles, which place the Witchblade in other times and settings. The character of Sara Pezzini was also featured in crossovers with characters from other franchises, including Lara Croft, JLA, the X-Men's Wolverine, and the cast of Battle of the Planets.

Witchblade was adapted into a moderately successful television series in 2001-2002, starring Yancy Butler as Sara Pezzini.

The title was also adapted into an anime and manga series in 2004. Each takes place in a futuristic Japan and features a new blade-wielder, with little resemblance to Pezzini or to each other, in the role. There have been two soundtracks to the comic books series (which had a limited print run).

A feature film, currently titled The Witchblade, is scheduled for a 2009 release.